What's new in VirHostnet 2.0 (release January 2019) ?
The Interology web service facilitates the prediction and visualisation of virus-virus and virus-host protein-protein interactions from raw primary protein sequences (in .fasta format).
Predictions rely on the principle of interology assumption, i.e. conservation of homologous protein-protein interactions during evolution. Protein-protein interactions are said to be interologs if the property of interaction between the protein partners and their respective homologous proteins is conserved during the race of virus-host co-evolution. Based on this hypothesis, it is possible to predict virus-virus or virus-host protein-protein interactions between viral strains or within a particular viral species or genus.
A short tutorial on how to use interology inference based on protein sequence homology is availabe here (EBOV predicted interaction network).
Past protein sequences in .fasta format:
OR Load a file of protein sequences from your local disk in .fasta format:
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