Surfing on the web of Virus/Host molecular interactions.

VirHostNet 2.0 (Virus-Host Network release 2.0) is a knowledgebase and a visualisation system dedicated to the network-based exploration of virus-host molecular interactions.

What's new in VirHostnet 2.0 (release January 2015) ?

• A 5-fold enrichment of virus/host and virus/virus ppi annotations since release 1.0.
  
• A VirHostNet SOLR PSICQUIC webservice that provides annotations in PSI MI-TAB 2.5 format (download).
  
• A brand new HTML5 web interface based on Cytoscape web, jquery and bootstrap libraries.
  
• An extension of virus/host ppi to non-human hosts.
  
• The use of UniProtkb/Swiss-Prot TrEMBL (release January 2015) and ReFSeQ (release 69 January 2015) as references.
  
• Virus' host range annotations provided by Uniprot/Viralzone are now used to highlight biologically relevant virus/host ppi.
  
• The use of UniProt domain feature key - including mature peptides - to annotate protein-protein interaction at a finer scale.
  
• Network-based nodes and edges properties (degree, betweeness, ...).
  
• An original BLAST webservice to infer novel virus/host ppi from sequences based on the assumption of interology.
  

#biocuration of the month:

• Global Mapping of Herpesvirus-Host Protein Complexes Reveals a Transcription Strategy for Late Genes. Davis ZH. et al. Molecular Cell. December 2014.
  [Pubmed] [VirHostNet] [psi-mi tab 2.5]
  Tweeter
• Influenza Virus-Host Interactome Screen as a Platform for Antiviral Drug Development. Watanabe T. et al. Cell Host Microbe. December 2014.
  [Pubmed] [VirHostNet] [psi-mi tab 2.5]
  Tweeter
• A proteome-scale map of the human interactome network. Roland T. et al. Cell. November 2014.
  [Pubmed] [VirHostNet] [psi-mi tab 2.5]
  Tweeter
• Elucidation of the Ebola Virus VP24 Cellular Interactome and Disruption of Virus Biology through Targeted Inhibition of Host-Cell Protein Function. García-Dorival I. et al. J. Prot. Res. November 2014.
  [Pubmed] [VirHostNet] [psi-mi tab 2.5]
  Tweeter