Surfing on the web of Virus/Host molecular interactions.

VirHostNet 2.0 (Virus-Host Network release 2.0) is a knowledgebase and a visualisation system dedicated to the network-based exploration of virus-host molecular interactions.

What's new in VirHostnet 2.0 (release January 2017) ?

• Automatic release since January 2015, following the UniProtkb/Swiss-prot TrEMBL releases
• Automatic accession number recovery since January 2017
• A 5-fold enrichment of virus/host and virus/virus ppi annotations since release 1.0
  
• A VirHostNet SOLR PSICQUIC webservice that provides annotations in PSI MI-TAB 2.5 format (download) including MIscore for virhostnet
  
• A brand new HTML5 web interface based on Cytoscape web, jquery and bootstrap libraries
  
• An extension of virus/host ppi to non-human hosts
  
• The use of UniProtkb/Swiss-Prot TrEMBL (release January 2017) and ReFSeQ (release 80 January 2017) as references
  
• The use of PSICQUIC webservice (January 19th 2017) to download BIND, INTACT, MINT, BIOGRID, DIP, Uniprot, MatrixDB, Innatedb, HPIDb protein-protein interaction data in PSI MI-TAB 2.5 format
• Virus' host range annotations provided by Uniprot/Viralzone are now used to highlight biologically relevant virus/host ppi
  
• The use of UniProt chain feature key - including mature peptides - to annotate protein-protein interaction at a finer scale
  
• The use of MIscore scoring function to measure the quality of each non-redundant interaction based on independant experiments information
  
• Network-based nodes and edges properties (degree, betweeness, ...)
  
• An original BLAST webservice to infer novel virus/host ppi from sequences based on the assumption of interology
  

Last #biocuration:

• Meta- and Orthogonal Integration of Influenza ‘‘OMICs’’ Data Defines a Role for UBR4 in Virus Budding Tripathi S. et al. Cell Host & Microbe January 2016.
  [Pubmed] [VirHostNet] [psi-mi tab 2.5]
  Tweeter
• Global Mapping of Herpesvirus-Host Protein Complexes Reveals a Transcription Strategy for Late Genes. Davis ZH. et al. Molecular Cell. December 2014.
  [Pubmed] [VirHostNet] [psi-mi tab 2.5]
  Tweeter
• Influenza Virus-Host Interactome Screen as a Platform for Antiviral Drug Development. Watanabe T. et al. Cell Host Microbe. December 2014.
  [Pubmed] [VirHostNet] [psi-mi tab 2.5]
  Tweeter
• A proteome-scale map of the human interactome network. Roland T. et al. Cell. November 2014.
  [Pubmed] [VirHostNet] [psi-mi tab 2.5]
  Tweeter
• Elucidation of the Ebola Virus VP24 Cellular Interactome and Disruption of Virus Biology through Targeted Inhibition of Host-Cell Protein Function. García-Dorival I. et al. J. Prot. Res. November 2014.
  [Pubmed] [VirHostNet] [psi-mi tab 2.5]
  Tweeter